FEMALE GENITAL TRACT QUIZ- OVARY (ANSWERS) Quiz on- Ovarian tumors. Each correct answer carries 5 marks. Answers will appear after each selection. Good luck!! What is the pTNM stage according to AJCC 8th edition of a malignant ovarian tumor. Both ovaries are involved and uterine implants are present. No nodal involvement or no other organ involvement is seen. A. pT1c N0 M0, Stage IC B. pT1c N0 M1b, Stage IVB C. pT2a N0 M0 Stage IIB D. pT3c N0 M1b, Stage IVB Which of the following precursors is marked correctly with the type of ovarian cancer arising from it? A. Serous borderline tumor- High grade serous carcinoma B. Benign Brenner tumor- Mucinous carcinoma C. Endometriosis- Low grade serous carcinoma D. All are true Most common site of Serous tubal intraepithelial carcinoma (STIC) lesion is? A.Fimbriae B.Ampulla C.Isthmus D.None Which of the following appearances of high grade serous carcinomas of ovary should raise suspicion and mandate testing for BRCA1 mutation Solid Mucinous Clear cell Papillary Which of the following is genes is implicated in the progression of Serous borderline ovarian tumor to low grade serous carcinoma? A. P53 B. RAS C. ARIDA D. BRCA In which of the following ovarian epithelial tumors is trastuzumab tried as a therapy? A. Mucinous B. Transtional C. Clear cell D. Endometrioid PARP- inhibitors are used in the therapy of which of the following ovarian epithelial tumors Clear cell carcinoma High grade serous ovarian epithelial tumors Transitional cell tumors Mucinous carcinoma Which of the following tumors is shown in the picture? On IHC staining, it has FOX L2 and Inhibin positive. (Reticulin stain shown in the picture) Add description here! Granulosa cell tumor Thecoma Fibroma Sertoli-leydig cell tumor A 55- year old female presents with post menopausal bleeding. An endometrial tumor was identified (morphology in image. She had a history of ovarian tumor resection 2 years back. Which of the following options represent the ovarian tumor Leydig cell tumor Serous borderline tumor Granulosa cell tumor Chronic Endometriosis 20-year-old woman who presented with abnormal uterine bleeding and abdominal pain. An adnexal mass was identified and surgical excision was performed. Histopathology is shown in the picture. Which of the following is true regarding the tumor? A. FOXL-2 mutations is present in majority of cases B. 50% tumors are bilateral C. Inhibin is a useful marker to differentiate this tumor from thecomas. D. Inhibin negative tumors are also calretinin negative Choriocarcinoma does NOT react immunohistochemically with which of the following? A. Inhibin B. hCG C. Human placental lactogen D. Pancytokeratin The finding shown in the picture is characteristic of which ovarian tumor? Leydig cell tumor Sertoli cell tumor Granulosa cell tumors Fibroma What differentiates a malignant Brenner tumor from an ovarian transitional cell tumor? A. History of a primary bladder tumor B. Mucinous metaplasia C. Presence of malignant components of transitional cells alone without benign or borderline components D. All of the above All of the following are associated with Peutz- Jehers syndrome except? A) Sertoli cell tumors B) Adenoma malignum C) Sertoli leydig cell tumor with annular tubules (STCAT) D) Brenner tumor True regarding the ovarian tumor shown in the picture is? A. Does not have a favorable prognosis B. Presence of severe atypia C. Presence of epithelial cells in sheets D. Presence of psammoma bodies in atleast >75% papillae in the rest Mixed malignant germ cell tumors of ovary are most commonly composed of which of the following components A. Dysgerminoma and yolk sac tumor B. Yolk sac tumor and embryonal carcinoma C. Dysgerminoma and embryonal carcinoma D. None of the above Identify the grade of teratoma, if the tumor contains moderate embryonal neural tissue >1 to < 4 low power fields? Grade I Grade II Grade III Immature neural tissue is not important in the grading of teratoma Which of the following laboratory parameters are increased in this tumor AFP CA-125 hCG PLAP A 40 - year old female presented with lower abdominal pain. On CT a right ovarian mass, the mass was excised, an H and E stained section is shown below. Which of the following is true regarding this tumor? A) Serum hCG and AFP are elevated in all tumors B) They are typically negative for CD30, SOX2, and glypican-3 C) OCT3/4 and glypican -3 are positive on IHC D) Granulomatous reaction is present in 100% of cases Germline truncating mutations in which of the following have been reported in sertoli and leydig cell tumor? TP53 DICER1 KRAS BRAF Which of the following ovarian tumor shows this characteristic finding Granulosa cell tumor Leydig cell tumor Sertoli cell tumor Dysgerminoma Time is Up! Time's up Share this:FacebookTelegramWhatsAppMoreLinkedInTwitterLike this:Like Loading...