FEMALE GENITAL TRACT QUIZ- OVARY (ANSWERS)

Quiz on- Ovarian tumors. Each correct answer carries 5 marks.

Answers will appear after each selection.

Good luck!!

What is the pTNM stage according to AJCC 8th edition of a malignant ovarian tumor. Both ovaries are involved and uterine implants are present. No nodal involvement or no other organ involvement is seen.

A. pT1c N0 M0, Stage IC

B. pT1c N0 M1b, Stage IVB

C. pT2a N0 M0 Stage IIB

D. pT3c N0 M1b, Stage IVB

None

Which of the following precursors is marked correctly with the type of ovarian cancer arising from it?

A. Serous borderline tumor- High grade serous carcinoma

B. Benign Brenner tumor- Mucinous carcinoma

C. Serous tubal intraepithelial carcinoma- Low grade serous carcinoma

D. All are true

None

Most common site of Serous tubal intraepithelial carcinoma (STIC) lesion is?

A.Fimbriae

B.Ampulla

C.Isthmus

D.None

None

Which of the following appearances of high grade serous carcinomas of ovary should raise suspicion and mandate testing for BRCA1 mutation

Solid

Mucinous

Clear cell

Papillary

None

Which of the following is genes is implicated in the progression of Serous borderline ovarian tumor to low grade serous carcinoma?

A. P53

B. RAS

C. ARIDA

D. BRCA

None

In which of the following ovarian epithelial tumors is trastuzumab tried as a therapy?

A. Mucinous

B. Transtional

C. Clear cell

D. Endometrioid

None

PARP- inhibitors are used in the therapy of which of the following ovarian epithelial tumors

Clear cell carcinoma

High grade serous ovarian epithelial tumors

Transitional cell tumors

Mucinous carcinoma

None

Which of the following tumors is shown in the picture? On IHC staining, it has FOX L2 and Inhibin positive. (Reticulin stain shown in the picture)

Add description here!

Granulosa cell tumor

Thecoma

Fibroma

Sertoli-leydig cell tumor

None

A 55- year old female presents with post menopausal bleeding. An endometrial tumor was identified (morphology in image. She had a history of ovarian tumor resection 2 years back. Which of the following options represent the ovarian tumor

Leydig cell tumor

Serous borderline tumor

Granulosa cell tumor

Chronic Endometriosis

None

20-year-old woman who presented with abnormal uterine bleeding and abdominal pain. An adnexal mass was identified and surgical excision was performed. Histopathology is shown in the picture. Which of the following is true regarding the tumor?

A. FOXL-2 mutations is present in majority of cases

B. 50% tumors are bilateral

C. Inhibin is a useful marker to differentiate this tumor from thecomas.

D. Inhibin negative tumors are also calretinin negative

None

Choriocarcinoma does NOT react immunohistochemically with which of the following?

A. Inhibin

B. hCG

C. Human placental lactogen

D. Pancytokeratin

None

The finding shown in the picture is characteristic of which ovarian tumor?

Leydig cell tumor

Sertoli cell tumor

Granulosa cell tumors

Fibroma

None

What differentiates a malignant Brenner tumor from an ovarian transitional cell tumor?

A. History of a primary bladder tumor

B. Mucinous metaplasia

C. Presence of malignant components of transitional cells alone without benign or borderline components

D. All of the above

None

All of the following are associated with Peutz- Jehers syndrome except?

A) Sertoli cell tumors

B) Adenoma malignum

C) Sertoli leydig cell tumor with annular tubules (STCAT)

D) Brenner tumor

None

True regarding the ovarian tumor shown in the picture is?

A. Does not have a favorable prognosis

B. Presence of severe atypia

C. Presence of epithelial cells in sheets

D. Presence of psammoma bodies in atleast >75% papillae in the rest

None

Mixed malignant germ cell tumors of ovary are most commonly composed of which of the following components

A. Dysgerminoma and yolk sac tumor

B. Yolk sac tumor and embryonal carcinoma

C. Dysgerminoma and embryonal carcinoma

D. None of the above

None

Identify the grade of teratoma, if the tumor contains moderate embryonal neural tissue >1 to < 4 low power fields?

Grade I

Grade II

Grade III

Immature neural tissue is not important in the grading of teratoma

None

Which of the following laboratory parameters are increased in this tumor

AFP

CA-125

hCG

PLAP

None

A 40 – year old female presented with lower abdominal pain. On CT a right ovarian mass, the mass was excised, an H and E stained section is shown below. Which of the following is true regarding this tumor?

A) Serum hCG and AFP are elevated in all tumors

B) They are typically negative for CD30, SOX2, and glypican-3

C) OCT3/4 and glypican -3 are positive on IHC

D) Granulomatous reaction is present in 100% of cases

None

Germline truncating mutations in which of the following have been reported in sertoli and leydig cell tumor?

TP53

DICER1

KRAS

BRAF

None

Which of the following ovarian tumor shows this characteristic finding

Granulosa cell tumor

Leydig cell tumor

Sertoli cell tumor

Dysgerminoma

None

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

Time’s up

You cannot switch tabs while taking this quiz!

You are not allowed to switch tabs violation has been recorded.

you cannot minimize full screen mode!

You are not allowed to minimize full screen while taking this quiz, violation has been recorded.

Access denied! To begin the quiz, please grant this quiz access to your camera.

Like this:

Like Loading…

9 responses to “FEMALE GENITAL TRACT QUIZ- OVARY (ANSWERS)”

Jyoti Priyadarshini Shrivastava

28 May 2021

Very interesting,so informative

Loading…

S

17 Jun 2021

Are the answers for question 8 and 9 correct. . ?

Loading…

1. pathologymcqs
  
  17 Jun 2021
  
  Yes answers are correct,
  Question 8: is to differentiate granulosa cell tumor and fibroma. Pericellular reticulin is characteristic of fibroma but not present in granulosa cell tumor.
  
  Question 9: The patient has an endometrial adenocarcinoma presently and a past history of ovarian tumor. Question is which ovarian tumor can causeendometrial carcinoma. Tumors characterized by hyperesteogenism like granulosa cell tumor, fibromas and thecomas can cause endometrial adenocarcinoma. In this question answer is granulosa cell tumor.
  
  Loading…
  
Dr.Umesh Chandra Dutta

19 Jun 2021

Good reasonable explanations of all answers.

Loading…

1. pathologymcqs
  
  19 Jun 2021
  
  Thank you. Glad you liked it! 🙂
  
  Loading…
  
Aishwarya_ thesailor

8 Dec 2022

FOXL2 mutation is seen in granulosa and not fibroma.

Loading…

1. Pathology MCQs
  
  8 Dec 2022
  
  FOXL2 mutation are a part of pathogenesis in sex-cord stromal tumors especially adult granulosa cell tumors and sertoli-leydig cell tumor. It is important to note that fibromas show positivity for FOX L2 immunostain even-though FOXL2 mutation is not observed. FOX L2 and inhibin are positive in fibromas by immunohistochemistry (as in granulosa cell tumor), hence cannot be used as a differentiating factor. Reticulin stain on the other hand shows peri-cellular staining in fibromas (shown in the question image), whereas granulosa cell tumors do not show pericellular pattern with reticulin. This can be useful in differentiating diffuse adult granulosa cell tumors from fibromas.
  
  Loading…
  
  1. Aishwarya_ thesailor
    
    15 Dec 2022
    
    Thanks. When are you coming up with your course for FRCPath?
    
    Loading…
  2. Pathology MCQs
    
    15 Dec 2022
    
    The course will start on 10th of January. Thanks for your interest. You may register for course updates https://mailchi.mp/7b509ac5ac9e/frcpath-histopathology-course-and-mock-test-registration.
    
    Loading…