What Robbins Pathologic Basis of Disease added in its 10th edition general pathology chapters, chapter by chapter, with the facts most likely to appear in NEET-PG, INI-CET and other entrance exams.
Chapter-wise updates
| Chapter | Update | Key fact |
|---|---|---|
| 1. The cell | Satellite DNA | Large arrays of repeats (5 bp to 5 kb) at centromeres; besides spindle attachment, they maintain tightly packed heterochromatin |
| 1. The cell | Gene editing with CRISPR–Cas9 | Clustered regularly interspaced short palindromic repeats guide the Cas9 nuclease to cut a chosen DNA sequence, allowing precise genome editing |
| 2. Cell injury and death | Ferroptosis | Described in 2012; iron-dependent lipid peroxidation that overwhelms glutathione-dependent (GPX4) antioxidant defences |
| 3. Inflammation and repair | Neutrophil extracellular traps | Expanded: chromatin webs that trap microbes; also a source of autoantigens and a driver of thrombosis |
| 6. Immunity | Transplant rejection | More detail on mechanisms of hyperacute, acute (cellular and antibody-mediated) and chronic rejection |
| 7. Neoplasia | New proto-oncogenes | FLT3 (point mutations or internal tandem duplications in leukaemia); GNAQ (uveal melanoma); GNAS (pituitary adenoma) |
| 7. Neoplasia | New tumour suppressors | SDHB and SDHD (succinate dehydrogenase, TCA cycle) in familial paraganglioma and phaeochromocytoma |
| 7. Neoplasia | HPV oncoproteins | E6 not only inactivates p53 but also increases telomerase (TERT) expression; E7 inactivates RB |
| 8. Infectious diseases | SARS-CoV-2 | Added coverage of the virus and COVID-19 |
Ferroptosis is a favourite one-liner: iron-dependent cell death from lipid peroxidation, prevented by GPX4. Remember also that HPV E6 raises TERT as well as degrading p53.
Practice questions
Ferroptosis is triggered mainly by:
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Besides inactivating p53, the HPV E6 protein:
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GNAQ point mutations are characteristic of:
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Kumar V, Abbas AK, Aster JC. Robbins and Cotran Pathologic Basis of Disease, 10th ed. Elsevier; 2020 · Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012;149:1060–1072
High-Yield, Board-Style Image MCQs & Interactive Whole Slide Images
High-resolution virtual microscopy with questions aligned to ABP, FRCPath, NEET-SS, DM Hematopathology and MD/DNB.
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