Subtitle: Free CNS tumours pathology MCQ PDF with answers for NEET-SS Oncopathology, DM, NIMHANS fellowships and FRCPath, plus a 10-question online quiz and a quick-reference table of key CNS tumours.
Author: PathologyMCQ Editorial Board
Category: Neuropathology
Last Updated: October 2026
Read Time: 4 minutes
At-a-Glance
- A free CNS tumours MCQ PDF with answers to download or read below.
- A 10-question online quiz with instant explanations.
- A quick-reference table of key CNS tumours, markers and molecular hallmarks.
- Useful for NEET-SS Oncopathology, DM Histopathology, NIMHANS neuropathology fellowships and FRCPath.
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Test Yourself: 10 MCQs
CNS tumours: 10 MCQs
Gliomas, meningioma, nerve sheath, embryonal and more, with instant explanations.
More practice: the CNS tumours MCQ bank โ
Quick Reference: Key CNS Tumours
| Tumour | Key IHC | Molecular hallmark | CNS WHO grade |
|---|---|---|---|
| Astrocytoma, IDH-mutant | IDH1 R132H+, ATRX loss, p53+ | IDH1/2; CDKN2A/B deletion = grade 4 | 2โ4 |
| Oligodendroglioma | IDH1 R132H+, ATRX retained | IDH + 1p/19q codeletion | 2โ3 |
| Glioblastoma, IDH-wildtype | IDH1 R132Hโ | TERT, EGFR, +7/โ10 | 4 |
| Pilocytic astrocytoma | GFAP, Olig2 | KIAA1549::BRAF | 1 |
| Ependymoma | GFAP, dot-like EMA | ZFTA, YAP1, PFA/PFB, MYCN | 2โ3 |
| Medulloblastoma | Synaptophysin; ฮฒ-catenin, GAB1, YAP1 | WNT, SHH, Group 3, Group 4 | 4 |
| AT/RT | INI1 loss | SMARCB1 | 4 |
| Meningioma | EMA, SSTR2A, PR | NF2; TERT, CDKN2A/B = grade 3 | 1โ3 |
| Solitary fibrous tumour | STAT6 nuclear, CD34 | NAB2::STAT6 | 1โ3 |
| Haemangioblastoma | Inhibin, S100; GFAPโ | VHL | 1 |
| Germinoma | OCT4, PLAP, c-KIT, D2-40 | KIT | Not graded |
More CNS Practice
Case-based quizzes: medulloblastoma โ ยท ependymoma โ ยท pilocytic astrocytoma โ
Topic reviews: WHO CNS5 updates โ ยท meningioma โ ยท medulloblastoma โ
More courses
Preparing for an exam?
Related reads: WHO CNS5 updates โ ยท Neuropathology Q-bank โ
Pathology MCQ app ยท Android
Get the Pathology MCQ app
Practise a slide and an MCQ every day, even when you are away from your desk.
- โDaily MCQ with explanations and streaks
- ๐ฌVirtual slides you pinch-zoom, with annotations
- ๐Your courses, notes and mocks in one place
References
- WHO Classification of Tumours Editorial Board. Central Nervous System Tumours. 5th ed. IARC; 2021.
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