Subtitle: Test yourself on paediatric renal tumours with 10 case-based MCQs: Wilms tumour syndromes and anaplasia, mesoblastic nephroma, clear cell sarcoma, rhabdoid tumour, translocation RCC and cystic nephroma.
Author: PathologyMCQ Editorial Board
Category: Paediatric and Renal Pathology
Last Updated: October 2026
Read Time: 5 minutes
At-a-Glance
- 10 case-based MCQs on paediatric renal tumours, with instant explanations.
- Covers Wilms tumour syndromes (WAGR, Denys–Drash, Beckwith–Wiedemann) and anaplasia.
- Also tests CMN, CCSK, rhabdoid tumour, translocation RCC and DICER1-related cystic nephroma.
- Revise first with the paediatric renal tumours summary →
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Test Yourself: 10 MCQs
Paediatric renal tumours quiz: 10 MCQs
Syndromes, histology, IHC and genetics, with instant explanations.
Score: 0 / 10
More practice: the renal pathology MCQ bank →
Quick Revision Sheet
Paediatric renal tumours: clue to diagnosis
| Clue | Think of |
|---|---|
| Triphasic blastema, epithelium, stroma | Wilms tumour |
| Nuclei ≥3× enlarged, multipolar mitoses | Anaplastic Wilms tumour (TP53) |
| Neonate, infiltrative spindle cells | Congenital mesoblastic nephroma |
| Chicken-wire vessels, bone metastasis | Clear cell sarcoma (BCOR ITD) |
| Macronucleoli, hyaline inclusions, brain tumour | Rhabdoid tumour (INI1 loss) |
| Adolescent, clear papillary cells, psammoma bodies | TFE3/TFEB translocation RCC |
| Multiloculated cyst, pleuropulmonary blastoma in family | Cystic nephroma (DICER1) |
Exam Pearls
- WAGR: 11p13 (WT1 + PAX6); Beckwith–Wiedemann: 11p15; Denys–Drash: WT1 missense.
- Focal anaplasia is confined to a circumscribed area; diffuse anaplasia carries worse prognosis.
- CCSK: BCOR+, cyclin D1+, WT1−.
- Rhabdoid tumour: INI1 loss; check for germline SMARCB1.
- Commonest paediatric RCC: MiT family translocation RCC.
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