Welcome to your Solid tumor cytogenetics MCQs

1. Array comparative genomic hybridization (aCGH) or chromosomal microarray analysis (CMA) would yield a normal result for which cytogenetic abnormality?
2. A solid tumor from a 25-year-old patient shows a translocation (X;18)(p11.2;q11.2). This is a characteristic finding in which setting?
3. A portion of a kidney mass obtained after radical nephrectomy from a 73-year-old male patient was submitted for cytogenetic workup. Karyotype analysis showed the loss of chromosomes 1, 2, 5, 6, 10, 13, 17, 21, and the Y chromosome (image). In addition, a t(3;8)(p21.3;p12) and trisomy 8 were identified. Based on the karyotypic loss of chromosomes, what is the most likely diagnosis?
Molecular pathology mcqs
4. Deletions of chromosomes 1p and 19q are of diagnostic and prognostic significance in which one of the following types of tumors of the nervous system?
5. A 16-year-old girl presented with a right shoulder mass, which was submitted for cytogenetic workup. The findings in surgical pathology identified tumor cells that were positive for CD99, beta-catenin, vimentin, and synaptophysin. Chromosome analysis performed after short-term cell culture showed a highly abnormal karyotype, as shown in( picture) . Based on the breakpoint at 22q12, FISH analysis was performed using an EWSR1 dual-color break-apart probe. Based on the karyotype and FISH analysis, what is the most likely diagnosis of this tumor?
Cytogenetics mcqs