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CYTOGENETICS IN HEMATOLOGY MCQs

Published by

Pathology MCQs

26 Jul 2021

Welcome to your CYTOGENETICS IN HEMATOLOGY MCQs

1. Bone marrow biopsy from a 40-year-old man with acute myeloid leukemia (AML) shows a preponderance of hypergranular promyelocytes and bundles of Auer rods. Which one of the following is the most likely karyotype in his bone marrow metaphase cells?

A. 46,XY,(8;21)(q22;q22).

B. 46,XY,inv(16)(p13q22).

C. 46,XY,t(4;11)(q21;q23).

D. 46,XY,t(15;17)(q24;q21).

E. 46,XY,inv(3)(q21q26).

None

2. Which one of the following chromosome abnormalities is associated with a poor prognosis in patients with MDS?

A. 46,XY,del(5)(q13q33).

B. 47,XY,+8.

C. 46,XY,del(20)(q11.2q13.3).

D. 45,X,-Y.

E. 46,XY,del(7)(q11.2q36).

None

3. The following karyogram is representative of nine cells from a bone marrow study. In addition, a high hyperdiploidy clone was observed with a t(9;22)translocation, and molecular studies revealed an IKZF1 deletion. What is the most likely diagnosis?

Molecular pathology / hematologymcqs