Subtitle: Soft tissue and bone tumour MCQs for NEET-SS, DM Oncopathology, FRCPath and board exams: sarcoma fusions, MDM2 amplification, histone and IDH mutations, STAT6, INI1, TFE3, brachyury and USP6, with 15 MCQs and a quick-review table (WHO 5th edition).
Author: PathologyMCQ Editorial Board
Category: Soft Tissue Pathology
Last Updated: October 2026
Read Time: 6 minutes
At-a-Glance
- 15 MCQs with explanations on soft tissue and bone tumours.
- Useful for NEET-SS, DM Oncopathology and Histopathology, oncopathology fellowships, FRCPath and American Board exams.
- Quick-review table of genetic drivers and surrogate IHC (WHO 5th edition).
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Test Yourself: 15 MCQs
Soft tissue and bone tumours: 15 MCQs
Fusions, amplifications, mutations and key IHC (WHO 5th edition), with instant explanations.
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Quick Review
| Tumour | Genetics | IHC / clue |
|---|---|---|
| Synovial sarcoma | SS18::SSX | SS18-SSX, TLE1 |
| Myxoid liposarcoma | FUS::DDIT3 (EWSR1::DDIT3) | DDIT3; chicken-wire vessels |
| ALT/WDLPS, DDLPS | MDM2, CDK4 amplification | MDM2, CDK4 (FISH preferred) |
| Alveolar rhabdomyosarcoma | PAX3/PAX7::FOXO1 | Diffuse myogenin |
| Low-grade fibromyxoid sarcoma | FUS::CREB3L2 | MUC4 |
| Solitary fibrous tumour | NAB2::STAT6 | Nuclear STAT6 |
| Epithelioid sarcoma | SMARCB1 loss | INI1 lost; keratin, CD34 |
| Alveolar soft part sarcoma | ASPSCR1::TFE3 | TFE3; PAS+ crystals |
| Ewing sarcoma | EWSR1::FLI1 / ERG | CD99, NKX2.2 |
| Giant cell tumour of bone | H3-3A G34W | H3.3 G34W |
| Chondroblastoma | H3-3B K36M | H3.3 K36M |
| Central chondrosarcoma | IDH1/IDH2 | — |
| Chordoma | TBXT gain | Brachyury |
| Nodular fasciitis, aneurysmal bone cyst | USP6 rearrangement | SMA (fasciitis) |
| Desmoid fibromatosis | CTNNB1 or APC | Nuclear beta-catenin |
| Inflammatory myofibroblastic tumour | ALK, ROS1, NTRK3 fusions | ALK |
More Topics
EWSR1-rearranged tumours → · Undifferentiated round cell sarcoma → · EWSR1::SMAD3 fibroblastic tumour → · Elastofibroma → · Epithelioid vascular tumours → · Chordoma → · GIST → · More pathology quizzes →
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Related reads: EWSR1-rearranged tumours → · Epithelioid vascular tumours →
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- ❓Daily MCQ with explanations and streaks
- 🔬Virtual slides you pinch-zoom, with annotations
- 📚Your courses, notes and mocks in one place
References
- WHO Classification of Tumours Editorial Board. Soft Tissue and Bone Tumours. 5th ed. IARC; 2020.
- Anderson WJ, Doyle LA. Updates from the 2020 World Health Organization classification of soft tissue and bone tumours. Histopathology. 2021;78:644–57.
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