GI Pathology quiz for pathology boards

Welcome to your GI Pathology quick quiz

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38. Which of the following is true regarding autoimmune gastritis?

A. Antibodies to H. Pylori are present

B. Can transform to type I carcinoid

C. Gastrin production is markedly decreased

D. Most commonly occurs in the gastric antrum

1 out of 10

A 60-year-old male with a history of chronic gastric conditions is being evaluated for potential gastric adenocarcinoma risk. Which of the following conditions does NOT result in gastric adenocarcinoma?

A) Menetrier disease

B) Gastric adenomas

C) Gastritis cystica

D) Autoimmune gastritis

E) Chronic H. Pylori infection

2 out of 10

A 45-year-old male with a family history of polyposis syndromes is found to have multiple colonic polyps. Genetic testing reveals MUTYH-related polyposis. Which statement is false regarding this condition?

A) APC gene is involved in the pathogenesis

B) Fewer polyps are present compared to familial adenomatous polyposis

C) Colon cancer development is later in onset compared to familial adenomatous polyposis

D) It is an Autosomal recessive syndrome

E) Associated with biallelic MUTYH mutations

3 out of 10

A 50-year-old patient with chronic gastritis undergoes biopsy. The pathologist uses the Sydney system for classification of gastritis. Which of the following morphological features is NOT graded in this system?

A) Atrophy

B) Inflammation

C) Intestinal metaplasia

D) Presence of granulomas

E) Lymphocytic infiltration

4 out of 10

A 38-year-old male presents with a history of polyposis syndromes. Genetic testing suggests does not suggest any significant genetic disturbance. Which of the following hereditary polyposis syndromes is NOT inherited in an autosomal dominant fashion?

A) Familial adenomatous polyposis

B) Turcot syndrome

C) Cronkchite Canada syndrome

D) Cowden syndrome

E) Lynch syndrome

5 out of 10

A 55-year-old patient is diagnosed with sporadic colon cancer during a routine colonoscopy. Which of the following genes is most commonly mutated in sporadic colon cancer?

A) MLH1

B) APC

C) MSH2

D) BRAF

E) KRAS

6 out of 10

A 43-year-old female presents with chronic diarrhea, abdominal pain, and weight loss. A biopsy reveals colonic inflammation. Which of the following histologic features is NOT characteristic of ulcerative colitis?

A) Presence of pseudopolyps

B) Presence of multiple strictutes

C) Pseudopyloric epithelial metaplasia

D) Inflammation limited to the superficial mucosa and submucosa

E) Crypt abscesses

7 out of 10

A 32-year-old female is diagnosed with a gastrointestinal stromal tumor (GIST) that shows loss of succinate dehydrogenase (SDH) staining. Which of the following statements about SDH-deficient GIST is FALSE?

A) Has a female preponderance

B) Strong immunoreactivity for SDHB

C) Exclusively occurs in the stomach

D) Affects young adult population

E) Commonly associated with germline SDH mutations

8 out of 10

A 45-year-old patient with a newly diagnosed gastrointestinal stromal tumor (GIST) is being evaluated for prognostic factors. Which of the following statements is FALSE regarding the prognostic factors of GIST?

A) Gastric GIST has a better prognosis.

B) Tumor rupture is also with a worse outcome

C) Kit exon 11 mutation is imatinib resistant

D) Tumor size > 10 cm is associated with a worse outcome.

E) Mitotic rate is an important prognostic factor

9 out of 10

A 39-year-old female is diagnosed with a rare gastric tumor suspected to be a clear cell sarcoma. Which gene mutation is commonly associated with gastric clear cell sarcoma?

A) FLT3

B) STAT3

C) SMAD2

D) EWSR1

E) MALAT1-GLI1

10 out of 10