Pathology MCQs for various entrance exams

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Answers will appear after each selection.

Classic astrocytoma has which of following microscopic features?

Widespread concentric calcifications

Fibrillary astrocytes in the background of loosely structured microcysts.

Cells with rounded vesicular nuclei with small distinct nucleoli, perinuclear halos, chicken wire vessels,

Microvessel proliferation and geographic necrosis

1 out of 20

Most IDH- mutant diffuse astrocytomas have which of the following mutations?

R132G

R132L

R132H

R132S

2 out of 20

Which of the following statements are true regarding astrocytomas?

Diffuse astrocytomas do not progress to IDH-mutant glioblastoma

IDH-mutant diffuse astrocytoma’s and IDH-wildtype glioblastomas develop from the same precursor population

IDH-mutant astrocyomas have a better prognosis compared to IDH- wildtype

Among IDH wildtype tumours, a genotype of 7q gain and 10q loss have a favourable outcome

3 out of 20

For a diagnosis of gemistocytes what is the cut-off percentage of gemistocytes required?

50%

30%

20%

10%

4 out of 20

Which one of the following is described among one of the Secondary structures of scherer?

Geographic necrosis

Perineural satellitosis

Microvascular proliferation

Scattered dense eosinophilic structures

5 out of 20

Most common genetic alteration associated with IDH-wildtype glioblastoma multiforme is?

TERT promoter mutations

Homozygous deletion of CDKN2A

Loss of chromosomes 10p

EGFR alterations

6 out of 20

All of the following brain tumors show p53 mutations except?

Primary glioblastoma in a child

Primary glioblastoma in an adult

Giant cell glioblastoma

None of the above

7 out of 20

All of the following brain tumors are associated with BRAF mutations except?

Supratentorial pilocytic astrocytoma

Ganglioglioma

Pleomorphic xanthoastrocytoma

Glioblastoma

8 out of 20

Which of the following features indicate an atypical meningioma (WHO grade II)?

Meningioma with 4 mitoses per 10 high-power fields

Meningioma with 20 mitoses per 10 high-power fields

Meningioma with necrosis but no other worrying features

Meningioma with CEA-immunopositive, PAS-positive secretory globules

9 out of 20

10.

True regarding small cell glioblastoma is?

Tumor cells show severe nuclear atypia

Often associated with EGFR amplification

Most of the tumors are IDH-mutated

All of the above

10 out of 20

11.

Identify the variant of glioblastoma from the image?

Identify ?

Small cell glioblastoma

Glioblastoma with epithelial component

Granular cell glioblastoma

Adenoid glioblastoma

11 out of 20

12.

Which of the following mutations are seen in diffuse midline gliomas?

H3K27M

EGFR

IDH

TERT

12 out of 20

13.

All of the following are good prognostic markers of glioblastoma multiforme except?

Age<50 years

Secondary glioblastoma

MGMT Promoter methylation

Presence of necrosis

13 out of 20

14.

Pilocytic astrocytomas occur commonly in which of the following locations in patients with neurofibromatosis type-1?

Frontal lobe

Thalamus

Optic nerve

Spinal cord

14 out of 20

15.

True statement about pilomyxoid astrocytoma are all except?

Has a monophasic architecture

Has a predominant myxoid background

Angiocentric pattern is very rare

Rosenthal fibers and eosinophilic bodies are very rare

15 out of 20

16.

Identify this tumor found in the in the intraventricular location?

Identify the tumor?

Ependymoma

Sub ependymal giant cell astrocytoma

Gemistocytic astrocytoma

Giant cell glioblstoma

16 out of 20

17.

What is the WHO grade of this tumor commonly arising from cauda equina, conus medullaris or filum terminale?

Grade I

Grade II

Grade III

Grade IV

17 out of 20

18.

All of the following are subtypes of ependymoma except?

Clear cell

Papillary

Tancytic

Giant cell

18 out of 20

19.

The picture is from a tumor in a 10-year old male in the lateral ventricle-the tumor cells are CK7 positive and transthyretin positive. What is the diagnosis?

RELA Fusion ependymoma

Choroid plexus papilloma

Astroblastoma

Pleomorphic xanthoastrocytoma

19 out of 20

20.

Which of the following brain tumors show dot like positivity for EMA ?

A. Medulloblastoma

B. Ependymoma

C. Diffuse astrocytoma

D. Meningioma

20 out of 20

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4 responses to “CNS-TUMORS PATHOLOGY MCQs”

Deborah Gomes

5 Mar 2023

Myxopapillary ependymoma is now grade II

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1. Pathology MCQs
  
  5 Mar 2023
  
  Yes, corrected! Thank you
  
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Dr Annie Jojo

2 Sep 2023

thank you

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Shagufta Iram

15 Dec 2023

Please also tell coreect option in addition to comments

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PATHOLOGY MCQs

CNS-TUMORS PATHOLOGY MCQs

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